Peer-reviewed veterinary case report
DNA vaccine for rabies triggers strong immune response in dogs
By Gupta, P K et al.·Published in Acta virologica·2009·Indian Veterinary Research Institute, India·View original on PubMed →
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Original publication title: Sindbis virus replicon-based DNA vaccine encoding Rabies virus glycoprotein elicits specific humoral and cellular immune response in dogs.
- Species:
- dog
Plain-English summary
A group of dogs received a new DNA vaccine designed to protect against rabies. The vaccine was injected into their ears and successfully triggered a strong immune response, producing protective antibodies against the rabies virus. Additionally, the vaccine increased specific immune cells that help fight off infections. This study shows that this innovative vaccine can effectively prepare dogs' immune systems to combat rabies.
People also search for: dog rabies vaccine effectiveness · rabies prevention in dogs · new rabies vaccine for dogs
Abstract
A Sindbis virus (SINV) replicon-based DNA vaccine encoding Rabies virus (RABV) glycoprotein G developed previously (Saxena et al., Vaccine 26, 6592, 2008) was used for immunization of dogs against rabies. The intradermal injection of DNA vaccine into external ear generated protective level of virus neutralizing antibodies. The cellular immune response was specific to RABV, in particular by an increase in CD3+CD4+ and CD3+CD8+ lymphocytes. This study has demonstrated that the SINV replicon-based DNA vaccine encoding RABV G is capable of inducing the protective level of specific immune response in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19537908/