Single administration of resveratrol improves social behavior in adult mouse models of autism spectrum disorder.

Abstract

Resveratrol (RSV) is a natural polyphenol present in grapes, the skin of peanuts, and several other plants with many health benefits. Autism spectrum disorder (ASD) is a neurodevelopmental disorder that may be linked to neural and synaptic development impairments. The present study aimed to analyze the preventive effects of RSV on the development of ASD-like behavior, usingknockout (-KO) and valproic acid-induced ASD (VPA-ASD) model mice. Genetic deficiencies inare suggested to be involved in ASD etiology. Twenty-four hours after a single RSV injection to the-KO mice, the social impairments caused by OXTR deficiency were ameliorated. RSV also improved social impairments in the VPA-ASD mice. Administration of RSV up-regulated(gene and() gene expressions in the amygdala of the-KO mice. Our data suggest that RSV may have therapeutic effects on ASD with multiple targets.