Peer-reviewed veterinary case report
Single low dose of 1cp-LSD tested for anxiety in a dog
By Henríquez-Hernández, Luis Alberto et al.·Published in Veterinary research communications·2024·Clinical Sciences Department, Spain·View original on PubMed →
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Original publication title: Single-dose 1cp-LSD administration for canine anxiety: a pilot study.
- Species:
- dog
Plain-English summary
A 13-year-old mixed-breed dog with a history of anxiety related to being left alone was given a single low dose of a substance called 1cp-LSD to see if it could help her feel less anxious. Initially, she showed the same level of anxiety during the first two hours of the trial, but after that, her behavior improved significantly, and she displayed little to no signs of anxiety. The trial lasted about five and a half hours, and there were no negative side effects observed. This suggests that 1cp-LSD may be a safe option for reducing anxiety in dogs.
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Abstract
Anxiety affects 14-20% of dogs. Pharmacological treatments often fail. Psychedelics have shown to be useful for anxiety and depression in humans, but their veterinary use remains unexplored. We aimed to determine the effects of low-dose 1-cyclopropionyl-d-lysergic acid diethylamide (1cp-LSD) administered in a single dose to a dog, to observe the effect and establish the safety of the substance. The patient was a 13-year-old female dog, weighing 13 kg, mixed breed, and spayed. A total of 5 µg was administered orally, equivalent to 0.38 µg/kg. The animal has had a history of separation related behavioral problems throughout her life. To objectively assess the degree of anxiety in the dog, a validated scale was utilized. The trial was scheduled at the house where the animal lives. The owner was present throughout the experience. Informed consent was obtained prior to the assay. The trial began at 12:15 p.m. on January 10, 2024, lasting for 5 and a half hours. The response to anxiety-inducing stimuli was equally anxious during the first two hours. From that point onwards, a significant change in the animal's behavior was observed, with no signs/mild signs of anxiety. The trial concluded without any adverse effects on the animal. The patient did not show signs of having a psychedelic experience. This is the first time that a study of this nature has been conducted and reported in the canine species. 1cp-LSD proved to be safe and exerted the desired effect on the animal's behavior, significantly reducing the patient's anxiety.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/39287896/