Peer-reviewed veterinary case report
Single-dose replication-defective VSV-based Nipah virus vaccines provide protection from lethal challenge in Syrian hamsters.
- Journal:
- Antiviral research
- Year:
- 2014
- Authors:
- Lo, Michael K et al.
- Affiliation:
- Viral Special Pathogens Branch · United States
- Species:
- rodent
Abstract
Nipah virus (NiV) continues to cause outbreaks of fatal human encephalitis due to spillover from its bat reservoir. We determined that a single dose of replication-defective vesicular stomatitis virus (VSV)-based vaccine vectors expressing either the NiV fusion (F) or attachment (G) glycoproteins protected hamsters from over 1000 times LD50 NiV challenge. This highly effective single-dose protection coupled with an enhanced safety profile makes these candidates ideal for potential use in livestock and humans.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/24184127/