Peer-reviewed veterinary case report
Gene variant linked to lower inflammatory bowel disease risk
By Peiravan, Atiyeh et al.·Published in Veterinary immunology and immunopathology·2016·Department of Clinical Sciences and Services, United Kingdom·View original on PubMed →
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Original publication title: Single nucleotide polymorphisms in major histocompatibility class II haplotypes are associated with potential resistance to inflammatory bowel disease in German shepherd dogs.
- Species:
- dog
Plain-English summary
German shepherd dogs in the UK are more likely to develop inflammatory bowel disease (IBD), which causes gastrointestinal issues. Researchers studied 56 German shepherds with IBD and 50 healthy ones to see if certain genetic markers were linked to the disease. They found that a specific genetic combination was only present in healthy dogs, suggesting it may help protect against IBD. Conversely, another genetic combination was associated with a higher risk of developing IBD. This information could help identify dogs at risk and guide future breeding practices.
People also search for: German shepherd IBD symptoms · inflammatory bowel disease in dogs · dog genetic testing for IBD
Abstract
German shepherd dogs (GSD) in the UK are at increased risk of developing the Inflammatory Bowel Disaese (IBD). IBD is believed to be a multifactorial immune mediated disease affecting genetically predisposed dogs. The aim of the current study was to investigate whether susceptibility to IBD in GSD is associated with the major histocompatibility complex (MHC) class II locus (Dog Leukocyte Antigen, DLA). Sequence-based genotyping of the three polymorphic DLA genes DLA-DRB1, -DQA1 and -DQB1 was performed in 56 GSDs affected by IBD and in 50 breed-matched controls without any history of gastrointestinal signs. The haplotype DLA-DRB1*015:02-DQA1*006:01-DQB1*023:01 was found to be present only in the control population and was associated with a reduced risk of IBD (P<0.001). In contrast, the haplotype DLA-DRB1*015:01-DQA1*006:01-DQB1*003:01 was associated with IBD (Odds ratio [OR]=1.93, confidence interval [CI]=1.02-3.67, P=0.05). This study has identified an association between DLA-type and canine IBD, supporting the immunogenetic aetiology and immunopathogenesis of this disease.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/27863539/