Peer-reviewed veterinary case report
Single nucleotide variations in thepromoter regulated piglet weight in the Min pig.
- Journal:
- Frontiers in veterinary science
- Year:
- 2025
- Authors:
- Han, Mingyang et al.
- Affiliation:
- College of Animal Science and Technology · China
Abstract
is a pleiotropic candidate gene, however its effect on piglet production trait remains unclear. In this study, a novel SNP: g.-519 A > G was identified in ANXA5 promoter. In Min pigs, association analysis showed the birth weight of AA animals at g.-674 C > A was higher than that of the AC or CC piglets ( < 0.05), while the heterozygous of g.-519 A > G had a higher weight than the homozygote at day 3, 7, 14, 21 after birth ( < 0.05). Porcineandexisted in piglets' gastrointestinal tract, and NR4A1 localized to the nucleus and cytoplasm which regulated the expression of. Luciferase reporter analysis demonstrated that the deletion of predictive NR4A1 binding region decreased the luciferase activity of porcinepromoter ( < 0.05), and the A allele of g.-519 A > G within this region had significantly higher luciferase activity than the G allele ( < 0.01). In conclusion, this research suggested that g.-519 A > G was a piglet weight variant that regulated the transcription ofpartially by NR4A1.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/41190166/