Peer-reviewed veterinary case report
Single-walled carbon nanotubes alleviate autophagic/lysosomal defects in primary glia from a mouse model of Alzheimer's disease.
- Journal:
- Nano letters
- Year:
- 2014
- Authors:
- Xue, Xue et al.
- Affiliation:
- CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety · China
- Species:
- rodent
Abstract
Defective autophagy in Alzheimer's disease (AD) promotes disease progression in diverse ways. Here, we demonstrate impaired autophagy flux in primary glial cells derived from CRND8 mice that overexpress mutant amyloid precursor protein (APP). Functionalized single-walled carbon nanotubes (SWNT) restored normal autophagy by reversing abnormal activation of mTOR signaling and deficits in lysosomal proteolysis, thereby facilitating elimination of autophagic substrates. These findings suggest SWNT as a novel neuroprotective approach to AD therapy.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/25115676/