Peer-reviewed veterinary case report
Signs and lab tests of lupus-like disease in three dogs
By Goudswaard, J et al.·Published in Tijdschrift voor diergeneeskunde·1993·Stichting Streeklaboratorium voor de Volksgezondheid·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: [SLE (systemic lupus erythematosus)-related clinical features in dogs].
- Species:
- dog
Plain-English summary
Three dogs were brought in for lameness and other unclear symptoms, which led to tests suggesting they might have systemic lupus erythematosus (SLE), an autoimmune disease. One dog had extremely high levels of certain antibodies, while two others showed low complement levels, indicating immune system issues. The findings highlighted the importance of specific immunological tests when SLE is suspected. Unfortunately, the abstract does not provide details on the treatments or outcomes for these dogs.
People also search for: dog lameness autoimmune disease · systemic lupus erythematosus in dogs · dog immune system problems
Abstract
Three dogs presented with lameness and/or vague clinical signs. The results of immunological tests were suggestive of a SLE-related syndrome. ANA (antinuclear antibodies) titres were very high, 1:40960 in one of the dogs, and antibodies against single-stranded DNA were detected. Complement levels were very low in two dogs. Antibodies against histones were detected in both the serum and the synovial fluid of one dog. In another dog there was evidence of high concentrations of PCNA antibodies, which in humans are specific for SLE. It is concluded that the three dogs showed signs of a syndrome possibly related to SLE. The description of the clinical signs and of the laboratory diagnostics serve as a clinical demonstration to draw colleagues' attention to this nosologically interesting clinical syndrome and to the need to request specific immunological tests when this syndrome is suspected.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/8465348/