Peer-reviewed veterinary case report
Sleep-disordered breathing after targeted ablation of preBötzinger complex neurons.
- Journal:
- Nature neuroscience
- Year:
- 2005
- Authors:
- McKay, Leanne C et al.
- Affiliation:
- Department of Neurobiology · United States
- Species:
- rodent
Abstract
Ablation of preBötzinger complex (preBötC) neurons, critical for respiratory rhythm generation, resulted in a progressive, increasingly severe disruption of respiratory pattern, initially during sleep and then also during wakefulness in adult rats. Sleep-disordered breathing is highly prevalent in elderly humans and in some patients with neurodegenerative disease. We propose that sleep-disordered breathing results from loss of preBötC neurons and could underlie death during sleep in these populations.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/16116455/