Peer-reviewed veterinary case report
SLIME: robust, high-speed 3D microvascular mapping.
- Journal:
- Scientific reports
- Year:
- 2019
- Authors:
- Liu, Yehe et al.
- Affiliation:
- Department of Biomedical Engineering · United States
Abstract
Three dimensional (3D) microvascular imaging of cubic millimeter to centimeter size volumes often requires much time and expensive instruments. By combining optical clearing with a novel scatter-based optical coherence tomography (OCT) contrast agent, we have greatly extended OCT imaging depth in excised tissues while maintaining a simple and low cost approach that does not require in-depth OCT knowledge. The new method enables fast 3D microvascular mapping in large tissue volumes, providing a promising tool for investigating organ level microvascular abnormalities in large cohorts.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/30696870/