Peer-reviewed veterinary case report
Brain tumor called solitary intracerebral plasmacytoma
By Van Wettere, A J et al.·Published in Veterinary pathology·2009·Department of Population Health and Pathobiology, United States·View original on PubMed →
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Original publication title: Solitary intracerebral plasmacytoma in a dog: microscopic, immunohistochemical, and molecular features.
- Species:
- dog
Plain-English summary
A 7-year-old spayed female Boston Terrier was diagnosed with a brain tumor after showing signs of neurological issues. The tumor was located in the left side of her brain and was identified as a solitary intracerebral plasmacytoma, which is a type of cancer involving plasma cells. This condition is quite rare in dogs. The diagnosis was confirmed through specialized testing that showed the tumor cells were clonal, meaning they originated from the same abnormal cell. Treatment options for this type of tumor can vary, so it's important for pet owners to discuss the best approach with their veterinarian.
People also search for: dog brain tumor symptoms · Boston Terrier cancer treatment · what is a plasmacytoma in dogs
Abstract
A primary intracerebral plasmacytoma was identified in a 7-year-old spayed female Boston Terrier. Grossly, a well-demarcated, 2 cm in diameter, roughly spherical tumor was in the rostral aspect of the left cerebral hemisphere. Histologically, the neoplasm was composed of sheets of round cells with distinct plasmacytoid features and marked anisocytosis and anisokaryosis. Cells were positive for vimentin, CD18, CD79a, and lambda light-chain, and negative for kappa light chain, cytokeratin, lysozyme, glial fibrillary acidic protein, and S100 protein. Clonally rearranged B-cell antigen receptor genes were detected by PARR (polymerase chain reaction for antigen receptor rearrangements), confirming clonal proliferation of B lymphocytes. Although primary solitary intracerebral plasmacytoma is rare in dogs and other species, it should be included in the differential diagnosis for central nervous system round-cell neoplasms. Clonality testing can be utilized to support the histological diagnosis of this neoplasm type.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19429998/