Peer-reviewed veterinary case report
Soluble epoxide hydrolase inhibitor tested for pain in horses
By Guedes, A et al.·Published in Equine veterinary journal·2017·Department of Veterinary Clinical Sciences, United States·View original on PubMed →
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Original publication title: Soluble epoxide hydrolase activity and pharmacologic inhibition in horses with chronic severe laminitis.
- Species:
- horse
Plain-English summary
A group of horses suffering from severe chronic laminitis (a painful hoof condition) was treated with a medication called t-TUCB to help manage their pain. The treatment lasted up to 10 days and resulted in a noticeable decrease in pain and improvement in their ability to lift their forelimbs. While one horse experienced gas colic and another had an eye issue during treatment, most horses showed significant relief from their symptoms. This suggests that using t-TUCB could be a helpful option for managing pain in horses with laminitis.
People also search for: horse laminitis pain treatment · t-TUCB for laminitis in horses · chronic laminitis management in horses
Abstract
BACKGROUND: The roles of soluble epoxide hydrolase and lipid mediators in inflammatory and neuropathic pain could be relevant in laminitis pain management. OBJECTIVES: To determine soluble epoxide hydrolase (sEH) activity in the digital laminae, sEH inhibitor potency in vitro, and efficacy of a sEH inhibitor as an adjunct analgesic therapy in chronic laminitic horses. STUDY DESIGN: In vitro experiments and clinical case series. METHODS: sEH activity was measured in digital laminae from euthanised healthy and laminitic horses (n = 5-6/group). Potency of 7 synthetic sEH inhibitors was determined in vitro using equine liver cytosol. One of them (t-TUCB; 0.1 mg/kg bwt i.v. every 24 h) was selected based on potency and stability, and used as adjunct therapy in 10 horses with severe chronic laminitis (Obel grades 2, one horse; 3-4, nine horses). Daily assessments of forelimb lifts, pain scores, physiologic and laboratory examinations were performed before (baseline) and during t-TUCB treatment. Data are presented as mean ± s.d. and 95% confidence intervals (CI). RESULTS: sEH activity in the digital laminae from laminitic horses (0.9±0.6 nmol/min/mg; 95% CI 0.16-1.55 nmol/min/mg) was significantly greater (P = 0.01) than in healthy horses (0.17±0.09 nmol/min/mg; CI 0.07-0.26 nmol/min/mg). t-TUCB as an adjunct analgesic up to 10 days (4.3±3 days) in laminitic horses was associated with significant reduction in forelimb lifts (36±22%; 95% CI 9-64%) and in pain scores (18±23%; 95% CI 2-35%) compared with baseline (P = 0.04). One horse developed gas colic and another corneal vascularisation in a blind eye during treatment. No other significant changes were observed. MAIN LIMITATIONS: Absence of control group and evaluator blinding in case series. CONCLUSIONS: sEH activity is significantly higher in the digital laminae of actively laminitic compared with healthy horses, and use of a potent inhibitor of equine sEH as adjunct analgesic therapy appears to decrease signs of pathologic pain in laminitic horses.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/27338788/