Peer-reviewed veterinary case report
Somatostatin cells in dog gut during normal and inflammatory bowel
By S. Gonkowski et al.·Published in European Journal of Inflammation·2013· Department of Clinical Physiology, Faculty of Veterinary Medicine, University of Warmia and Mazury, Olsztyn, Poland, GB·View original on DOAJ →
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Original publication title: Somatostatin as an Active Substance of Enteroendocrine Cells in the Canine Digestive Tract in Physiological Conditions and during Inflammatory Bowel Disease
- Species:
- dog
Plain-English summary
A study found that dogs with inflammatory bowel disease (IBD) had an increased number of certain cells in their stomach and small intestine that produce a hormone called somatostatin. These changes were not seen in the duodenum or colon. The researchers suggest that somatostatin might play a role in the problems caused by IBD in dogs. This could lead to new treatment options for dogs suffering from this condition in the future.
People also search for: dog inflammatory bowel disease symptoms · somatostatin treatment for dogs · dog stomach problems IBD
Abstract
The aim of the present investigation is to examine the changes in the number of somatostatin-like immunoreactive (SOM-LI) enteroendocrine cells in various parts of the canine gastrointestinal (GI) tract during canine inflammatory bowel disease (IBD). The distribution of SOM-LI enteroendocrine cells was studied using the double-labeling immunofluorescence technique with antisera against chromogranin A (CgA; used here as a marker of enteroendocrine cells) and somatostatin (SOM). Evaluation of the number of CgA-positive cells, which also contained SOM in the mucosal layer of canine stomach, duodenum, jejunum and descending colon was based on the counting of such cells per unit area (0.1 mm 2 ). In physiological conditions, the number of SOM-LI enteroendocrine cells has been shown to constitute 5.30±2.07 in the stomach, 2.23±0.56 in the duodenum, 1.86±0.48 in the jejunum and 1.19±0.36 in the descending colon. Canine IBD caused an increase in the number of cells studied in the stomach (to 9.55±1.46) and the jejunum (to 3.84±1.16), while the changes observed in the duodenum and the descending colon have not been statistically significant. The obtained results suggest that SOM-LI enteroendocrine cells, as well as somatostatin, may be involved in pathological processes during canine IBD. Moreover, this study can be treated as the first step of application of SOM and/or its analogues in the treatment of canine IBD in the future.
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Search related cases →Original publication on DOAJ: https://doi.org/10.1177/1721727X1301100309