Peer-reviewed veterinary case report
Dog with polycythaemia vera showing blood cell metabolism changes
By Comazzi, S et al.·Published in The Veterinary record·2000·Istituto di Patologia Generale Veterinaria, Italy·View original on PubMed →
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Original publication title: Some aspects of erythrocyte metabolism in a dog with polycythaemia vera.
- Species:
- dog
Plain-English summary
An 11-year-old female crossbred dog was brought in for excessive urination and thirst, vomiting, weakness in her back legs, and difficulty walking. The vet diagnosed her with polycythemia vera, a condition where the body produces too many red blood cells. Over six months, tests showed some irregularities in her red blood cell function, but her overall condition was stable. The dog received treatment aimed at managing her symptoms, and while the specifics of her recovery weren't detailed, she was monitored closely for changes in her health.
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Abstract
An 11-year-old female crossbred dog showed signs of polyuria, polydipsia, vomiting, posterior weakness and ataxia. Clinical and laboratory findings suggested the diagnosis of polycythaemia vera. The haematological values shown over a six-month period are presented. In four samples some aspects of erythrocyte function (glucose-6-phosphate dehydrogenase [G6PD] and pyruvate kinase [PK] activities, 2,3 diphosphoglycerate [2,3 DPG] concentration, osmotic fragility and intracellular sodium and potassium concentrations) were studied. Variable activities of G6PD and PK, probably related to different reticulocyte number, were detected together with normal osmotic fragility and intracellular sodium and potassium concentrations. 2,3 DPG concentration was higher than normal in all four samples. This could be interpreted as a response to a low tissue perfusion rather than a higher content of 2,3 DPG in red blood cells from the polycythaemic dog.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/11058023/