Peer-reviewed veterinary case report
Sonication induced intermediate in prion protein conversion.
- Journal:
- Protein and peptide letters
- Year:
- 2008
- Authors:
- Zukas, Audrius A et al.
- Affiliation:
- United States Department of Agriculture · United States
- Species:
- rodent
Abstract
We have observed that hamster prion protein (PrP(C)) undergoes conformational changes on exposure to heat or sonication. If a sonication induced new conformer is seeded with a small amount of its abnormal pathogenic isoform (PrP(Sc)) it undergoes a significant conversion to a proteinase-resistant isoform. This suggests the presence of a third stable PrP conformer, which may be intermediate in the conversion of PrP(C) to PrP(Sc).
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/18289112/