Peer-reviewed veterinary case report
How well blood test cPE-1 detects pancreatitis in dogs
By Mansfield, Caroline S et al.·Published in Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·2011·Department of Veterinary Clinical Science, Australia·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Specificity and sensitivity of serum canine pancreatic elastase-1 concentration in the diagnosis of pancreatitis.
- Species:
- dog
Plain-English summary
A group of dogs showing signs of pancreatitis, like vomiting and abdominal pain, were tested for a specific protein in their blood called canine pancreatic elastase-1 (cPE-1) to see if it could help diagnose their condition. The study included 61 dogs, with 49 having pancreatic disease and 12 without. While the test showed good results for identifying severe acute pancreatitis, it wasn't as effective for chronic or mild cases. Overall, the cPE-1 test had a high accuracy for severe cases, helping vets make better diagnoses and treatment plans for affected dogs.
People also search for: dog pancreatitis symptoms · dog blood test for pancreatitis · how to treat severe pancreatitis in dogs
Abstract
The aim of the current study was to determine the sensitivity and specificity of serum canine pancreatic elastase-1 (cPE-1) for the diagnosis of pancreatitis in dogs. The study was prospective, assessing dogs presenting with clinical signs similar to pancreatitis. Sixty-one dogs were recruited (49 with pancreatic disease and 12 with non-pancreatic disease). There was no significant difference in serum cPE-1 between dogs with pancreatic disease and non-pancreatic disease. However, there was a significant difference in serum cPE-1 between severe acute pancreatitis and non-pancreatic disease. A cut-off value for serum cPE-1 > 17.24 ng/ml resulted in sensitivity of 61.4% and specificity of 91.7% for diagnosis of all types of pancreatic disease. The sensitivity rose to 65.85% and 78.26% for the diagnosis of all types of acute pancreatitis and severe acute pancreatitis, respectively. Serum cPE-1 is more sensitive at diagnosing severe acute pancreatitis than chronic or mild acute pancreatitis, and has a high positive likelihood ratio. Dogs with chronic pancreatitis tended to have lower serum cPE-1 concentration, suggesting decreased exocrine function.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21908310/