Peer-reviewed veterinary case report
Specificity of vascular endothelial growth factor treatment for radiation necrosis.
- Journal:
- Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
- Year:
- 2015
- Authors:
- Perez-Torres, Carlos J et al.
- Affiliation:
- Department of Radiology · United States
Abstract
Recently, radiation induced necrosis in the brain has been treated using bevacizumab, an anti-VEGF antibody. We validated the VEGF specificity by comparing the therapeutic efficacy of anti-VEGF with non-specific isotype control antibody. Additionally, we found that VEGF over-expression and RN developed simultaneously, which precludes preventative anti-VEGF treatment.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/26376163/