Peer-reviewed veterinary case report
Sphingomyelinase deficiency (Niemann-Pick disease) in a Hereford calf.
- Journal:
- Veterinary pathology
- Year:
- 2008
- Authors:
- Saunders, G K & Wenger, D A
- Affiliation:
- College of Veterinary Medicine · United States
Abstract
A 5-month-old Hereford calf with neurologic disease was euthanatized, and a necropsy was done. No gross lesions were seen in the brain. Microscopically, neurons throughout the brain and spinal cord had distended, foamy vacuolated cytoplasm. Ultrastructure showed clear vacuoles filling the neuronal cytoplasm. A lysosomal storage disease was suspected. Sphingomyelinase deficiency was confirmed by biochemical analysis of liver and brain.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/18424834/