Peer-reviewed veterinary case report
Sphingosine-1-phosphate Receptor Agonism Reduces Bordetella pertussis-mediated Lung Pathology.
- Journal:
- The Journal of infectious diseases
- Year:
- 2015
- Authors:
- Skerry, Ciaran et al.
- Affiliation:
- Department of Microbiology and Immunology
- Species:
- rodent
Abstract
Recent pertussis resurgence represents a major public health concern. Currently, there are no effective treatments for critical pertussis in infants. Recent data have demonstrated the potential of sphingosine-1-phosphate receptor (S1PR) agonism in the treatment of infectious diseases. We used the murine Bordetella pertussis model to test the hypothesis that treatment with S1PR agonist AAL-R reduces pulmonary inflammation during infection. AAL-R treatment resulted in reduced expression of inflammatory cytokines and chemokines and attenuated lung pathology in infected mice. These results demonstrate a role for sphingosine-1-phosphate (S1P) signaling in B. pertussis-mediated pathology and highlight the possibility of host-targeted therapy for pertussis.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/25538274/