Peer-reviewed veterinary case report
Spinal neural cyclooxygenase-2 mediates pain caused in a rat model of lumbar disk herniation.
- Journal:
- The journal of pain
- Year:
- 2004
- Authors:
- Ohtori, Seiji et al.
- Affiliation:
- Department of Orthopedic Surgery · Japan
- Species:
- rodent
Abstract
UNLABELLED: Application of nucleus pulposus to nerve root generates radicular pain. We demonstrated that these animals showed allodynia for 2 weeks, and cyclooxygenase-2 (COX-2) immunoreactivities were up-regulated in the spinal dorsal horn. COX-2 immunoreactivities were shown in neurons; however, they were not in astrocytes. Intrathecal administration of an antibody to COX-2 decreased allodynia. Our results suggest that COX-2 in spinal cord might be a target for treatment of patients with nerve root pain caused by lumbar disk herniation. PERSPECTIVE: Neural COX-2 might mediate nerve root pain in the spinal cord caused by lumbar disk herniation in rats.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/15501196/