Peer-reviewed veterinary case report
Dog with acute erythroblastic leukemia
By Tomiyasu, H et al.·Published in The Journal of small animal practice·2011·Department of Veterinary Internal Medicine, Japan·View original on PubMed →
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Original publication title: Spontaneous acute erythroblastic leukaemia (AML-M6Er) in a dog.
- Species:
- dog
Plain-English summary
A 5-year-old golden retriever was brought to the vet because he was very tired, not eating, and had low red blood cells and platelets. Tests showed he had a serious blood cancer called acute erythroblastic leukemia (AML-M6Er), which was confirmed by examining his blood and bone marrow. Unfortunately, despite starting chemotherapy with a drug called cytarabine, the dog passed away just two days later. This case highlights a rare form of leukemia in dogs.
People also search for: dog anemia symptoms · golden retriever lethargy and not eating · dog leukemia treatment options
Abstract
A five-year-old golden retriever was presented with anaemia, thrombocytopenia, anorexia and lethargy. Peripheral blood cytology showed abnormal cells similar to proerythroblasts with multiple nucleoli and strongly basophilic cytoplasm. Bone marrow cytopathology revealed that the blast cells accounted for more than 80% of all nucleated cells (ANC). These blast cells were confirmed as erythroblastic cells by cytochemistry, polymerase chain reaction for genetic clonality assessment of IgH and TCRγ, flow cytometry, and transmission electron microscopy. Based on these observations, the dog was diagnosed with acute erythroblastic leukaemia (AML-M6Er). Chemotherapy with cytarabine commenced on day 7 after initial presentation, but the dog died 2 days later. This is the first report of spontaneous AML-M6Er in a dog.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21797877/