Peer-reviewed veterinary case report
Cat with mouth and eye cancer linked to papillomavirus type 3
By Munday, John S et al.·Published in Veterinary pathology·2022·Massey University·View original on PubMed →
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Original publication title: squamous cell carcinoma of the gingiva and nictitating membrane associated withpapillomavirus type 3 in a cat.
- Species:
- cat
Plain-English summary
A 10-year-old domestic shorthair cat developed squamous cell carcinomas (a type of cancer) on its gums and third eyelid. These cancers were linked to a virus known as papillomavirus type 3, which was found in the cancer cells. This case is significant because it suggests that this virus might play a role in causing oral cancers in cats. The cat's treatment details weren't specified, but early detection and intervention are crucial for managing such cancers.
People also search for: cat oral cancer symptoms · papillomavirus in cats · cat third eyelid tumor treatment
Abstract
Oral squamous cell carcinomas (OSCCs) are common cancers of cats. While papillomaviruses (PVs) are an important cause of human OSCCs, there is currently little evidence that PVs cause squamous cell carcinomas (SCCs) of the mouth or other mucosal surfaces in cats. In the present cat,carcinomas developed on the gingiva and nictitating membrane. Neoplastic cells within both cancers contained prominent PV-induced cellular changes consistent with those caused byPV3 (FcaPV3), and FcaPV3 DNA was amplified from both cancers. Neoplasms also contained intense nuclear and cytoplasmic p16protein (p16) immunolabeling, suggesting PV-induced degradation of retinoblastoma protein. The molecular and histological features strongly suggested the cancers were caused by FcaPV3 infection. This is the first report of an association between PV infection and the development of ancarcinoma of the mucosa of cats. The identification of these lesions suggests that PVs might cause a proportion of OSCCs, and SCCs from other mucosal surfaces, in cats.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/35220854/