Peer-reviewed veterinary case report
Norwegian Elkhound females with Sry-negative XX sex reversal
By Melniczek, J R et al.·Published in Journal of veterinary internal medicine·1999·Department of Clinical Studies, United States·View original on PubMed →
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Original publication title: Sry-negative XX sex reversal in a family of Norwegian Elkhounds.
- Species:
- dog
Plain-English summary
Two related female Norwegian Elkhounds, aged 6 and 8 months, were brought in for examination due to enlarged clitorises. Testing revealed that one dog was a true hermaphrodite with both ovarian and testicular tissue, while the other was identified as an XX male with non-functioning testes. Genetic testing showed both dogs lacked the Sry gene, which is crucial for male development. This case highlights a rare genetic condition in this breed, and while specific treatments weren't mentioned, understanding the condition can help guide future care.
People also search for: Norwegian Elkhound sex reversal · dog enlarged clitoris · XX male dog condition · hermaphrodite dog symptoms
Abstract
Two related female Norwegian Elkhounds were evaluated at 6 and 8 months of age for enlarged clitori. Both had a 78 XX karyotype. Histology of their internal reproductive tracts demonstrated 1 to be an XX true hermaphrodite with bilateral ovotestes and the other to be an XX male with bilateral aspermatogenic testes. Polymerase chain reaction-based tests of genomic DNA showed that both dogs lacked Sry, the testis-determining gene. Pedigree analysis was consistent with an autosomal recessive mode of inheritance, as has been reported in the American Cocker Spaniel and the German Shorthaired Pointer. This is the 1st reported case of familial Sry-negative XX sex reversal in the Norwegian Elkhound. A summary of 34 previously unreported cases of dogs with masculinized external genitalia and a normal 78 XX karyotype seen from 1980 to 1997 is given.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/10587257/