Peer-reviewed veterinary case report
Serum 3-bromotyrosine levels in dogs with gut diseases
By Sattasathuchana, Panpicha et al.·Published in BMC veterinary research·2015·College of Veterinary Medicine, United States·View original on PubMed →
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Original publication title: Stability of 3-bromotyrosine in serum and serum 3-bromotyrosine concentrations in dogs with gastrointestinal diseases.
- Species:
- dog
Plain-English summary
A group of dogs with gastrointestinal issues, including eosinophilic gastroenteritis (EGE), lymphocytic-plasmacytic enteritis (LPE), and pancreatitis, were tested for a substance called 3-bromotyrosine (3-BrY) in their blood. The results showed that dogs with EGE had significantly higher levels of 3-BrY compared to healthy dogs, indicating that this marker could help in diagnosing certain gastrointestinal diseases. However, dogs with exocrine pancreatic insufficiency (EPI) did not show a difference in 3-BrY levels compared to healthy dogs. This suggests that while 3-BrY may be useful for some conditions, more research is needed to confirm its effectiveness in diagnosing these gastrointestinal issues.
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Abstract
BACKGROUND: 3-Bromotyrosine (3-BrY) is a stable product of eosinophil peroxidase and may serve as a marker of eosinophil activation. A gas chromatography/mass spectrometry method to measure 3-BrY concentrations in serum from dogs has recently been established and analytically validated. The aims of this study were to determine the stability of 3-BrY in serum, to determine the association between peripheral eosinophil counts and the presence of an eosinophilic infiltrate in the gastrointestinal tract, and to compare serum 3-BrY concentrations in healthy dogs (n = 52) and dogs with eosinophilic gastroenteritis (EGE; n = 27), lymphocytic-plasmacytic enteritis (LPE; n = 25), exocrine pancreatic insufficiency (EPI; n = 26), or pancreatitis (n = 27). RESULTS: Serum 3-BrY concentrations were stable for up to 8, 30, and 180 days at 4°C, -20°C, and -80°C, respectively. There was no significant association between peripheral eosinophil count and the presence of eosinophils in the GI tissues (P = 0.1733). Serum 3-BrY concentrations were significantly higher in dogs with EGE (median [range] = 5.04 [≤0.63-26.26] μmol/L), LPE (median [range] = 3.60 [≤0.63-15.67] μmol/L), and pancreatitis (median [range] = 1.49 [≤0.63-4.46] μmol/L) than in healthy control dogs (median [range] = ≤0.63 [≤0.63-1.79] μmol/L; P < 0.0001), whereas concentrations in dogs with EPI (median [range] = 0.73 [≤0.63-4.59] μmol/L) were not different compared to healthy control dogs. CONCLUSIONS: The present study revealed that 3-BrY concentrations were stable in serum when refrigerated and frozen. No relationship between peripheral eosinophil count and the presence of eosinophils infiltration in the GI tissues was found in this study. In addition, serum 3-BrY concentrations were increased in dogs with EGE, but also in dogs with LPE and pancreatitis. Further studies are needed to determine whether measurement of 3-BrY concentrations in serum may be useful to assess patients with suspected or confirmed EGE or LPE.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25595676/