Peer-reviewed veterinary case report
Stability of trilostane in cod liver oil for small dogs
By Crosby, Jesse & Brown, Stacy·Published in Veterinary journal (London, England : 1997)·2017·Department of Pharmaceutical Sciences, United States·View original on PubMed →
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Original publication title: Stability of compounded trilostane suspension in cod liver oil.
- Species:
- dog
Plain-English summary
A small dog with Cushing's disease (hyperadrenocorticism) may need a precise dose of trilostane, a medication that can be hard to give in standard tablet form. Compounding trilostane in cod liver oil makes it easier to administer and adjust the dose. Research showed that this liquid form stayed stable for 60 days when kept in amber glass bottles, but lost potency quickly in amber plastic bottles. This means that if your vet prescribes this compounded medication, it's best to store it properly to ensure it remains effective.
People also search for: dog Cushing's disease treatment · trilostane for dogs · compounded medication for dogs
Abstract
Trilostane is a synthetic steroid analog used to treat canine hyperadrenocorticism. For small dogs, the dose found in commercially available dosage forms of trilostane is sometimes too high. Compounding trilostane in a liquid diluent provides an option for more precise dosing and adjustments, and can be easier to administer, versus a tablet or capsule. Trilostane suspends well in cod liver oil, which is generally palatable to dogs. The stability of a compounded trilostane suspension in cod liver oil stored at room temperature was investigated for 90 days. Compounded trilostane retained stability, defined as maintaining 90-105% labeled value, for 60 days when stored in amber glass bottles. However, drug potency fell >10% below the labeled value when stored in amber plastic bottles after 7 days.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/29153102/