Peer-reviewed veterinary case report
Stage-specific embryonic antigen: determining expression in canine glioblastoma, melanoma, and mammary cancer cells.
- Journal:
- Journal of veterinary science
- Year:
- 2017
- Authors:
- Lin, Weiming et al.
- Affiliation:
- Department of Veterinary Clinical Sciences and Masonic Cancer Center · United States
- Species:
- dog
Abstract
The expression of stage-specific embryonic antigens (SSEAs) was determined in several types of canine cancer cells. Flow cytometry showed SSEA-1 expression in glioblastoma, melanoma, and mammary cancer cells, although none expressed SSEA-3 or SSEA-4. Expression of SSEA-1 was not detected in lymphoma, osteosarcoma, or hemangiosarcoma cell lines. Relatively stable SSEA-1 expression was observed between 24 and 72 h of culture. After 8 days in culture, sorted SSEA-1and SSEA-1cells re-established SSEA-1 expression to levels comparable to those observed in unsorted cells. Our results document, for the first time, the expression of SSEA-1 in several canine cancer cell lines.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/27456773/