Peer-reviewed veterinary case report
Starving Bacteria of Iron: A Potential Strategy to Disperse Bacterial Biofilms.
- Journal:
- Journal of medicinal chemistry
- Year:
- 2021
- Authors:
- Naclerio, George A & Sintim, Herman O
- Affiliation:
- Chemistry Department · United States
Abstract
Halogenated phenazines (HPs) are potent antimicrobial agents. A newly developed halogenated phenazine, HP-, displays remarkable minimum inhibitory concentration (MIC) of 0.08 μM against methicillin-resistant, MRSA. HP-eradicates preformed biofilm via iron starvation, is nontoxic to mammalian cell lines and is efficacious in wound infection models.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/33988992/