Peer-reviewed veterinary case report
Statins do not reduce the parasite burden during experimentalinfection.
- Journal:
- Antimicrobial agents and chemotherapy
- Year:
- 2025
- Authors:
- Razzaq, Sarah et al.
- Affiliation:
- Department of Infection Biology · United Kingdom
Abstract
Cardiomyopathy is the most common pathology associated withinfection. Reports that statins have both cardioprotective and trypanocidal activity have generated interest in their potential as a therapeutic treatment. Using a highly sensitive bioluminescent mouse model, we show that a 5-day treatment with statins has no significant impact on parasite load. The free systemic concentrations fail to reach the level required for potency. Hence, clinical trials to investigate the trypanocidal activity of statins lack experimental justification.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/40331859/