Peer-reviewed veterinary case report
Status of therapeutic gene transfer to treat canine dilated cardiomyopathy in dogs.
- Journal:
- The Veterinary clinics of North America. Small animal practice
- Year:
- 2010
- Authors:
- Sleeper, Meg M et al.
- Affiliation:
- Department of Clinical Studies · United States
- Species:
- dog
Abstract
Therapeutic gene transfer holds promise as a way to treat dilated cardiomyopathy from any underlying cause because the approach attempts to address metabolic disturbances that occur at the molecular level of the failing heart. Calcium-handling abnormalities and increased rates of apoptosis are abnormalities that occur in many types of heart disease, and gene therapies that target these metabolic defects have proven to be beneficial in numerous rodent models of heart disease. The authors are currently evaluating this approach to treat canine idiopathic dilated cardiomyopathy.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/20610021/