Peer-reviewed veterinary case report
Stent-Based Gene Delivery for Coronary Disease.
- Year:
- 2022
- Authors:
- Alferiev IS et al.
- Affiliation:
- The Children's Hospital of Philadelphia · United States
Abstract
Percutaneous coronary interventions (PCI) are the mainstay for treatment of advanced coronary disease. A majority of PCI involve deployment of a stent in the affected vascular segment. This chapter introduces the concept of using stents as a platform for delivering gene therapies to the vasculature with the overarching aim of mitigating in-stent restenosis (ISR), late stent thrombosis (LST), and neoatherosclerosis (NA), a triad of delayed complications that reduce the overall success rate of PCI. The chapter provides a detailed methodology for coatless reversible attachment of adenoviral (Ad) and adeno-associated viral (AAV) vectors to the metal stent struts along with representative in vitro and in vivo results.
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Search related cases →Original publication: https://europepmc.org/article/MED/36040598