Peer-reviewed veterinary case report
Sterilizing Effects of Novel Regimens Containing TB47, Clofazimine, and Linezolid in a Murine Model of Tuberculosis.
- Journal:
- Antimicrobial agents and chemotherapy
- Year:
- 2021
- Authors:
- Yu, Wei et al.
- Affiliation:
- State Key Laboratory of Respiratory Disease · China
Abstract
TB47, a new drug candidate targeting QcrB in the electron transport chain, has shown a unique synergistic activity with clofazimine and forms a highly sterilizing combination. Here, we investigated the sterilizing effects of several all-oral regimens containing TB47 plus clofazimine and linezolid as a block and the roles of fluoroquinolones and pyrazinamide in them. All these regimens cured tuberculosis within 4 to 6 months in a well-established mouse model, and adding pyrazinamide showed a significant difference in bactericidal effects.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/34280022/