STIMULATION OF B3-RECEPTOR-INDUCED CENTRAL NEUROGENIC EDEMA AND VITIATED ELECTROLYTE HOMEOSTASIS IN EXPERIMENTAL RODENT MODEL.

Abstract

Mirabegron is one of the recently introduced treatments for overactive bladder which avoids the undue effects of antimuscarinics such as constipation, headache, and dry mouth. This study investigated chronic relatively high doses of beta3 adrenergic receptor activation effect on electrolyte hemostasis and possible consequence on the central nervous system viability. In the present study, serum sodium, potassium, chloride, and calcium ion levels using flame photometry had been measured and eosin and hematoxylin staining for cerebral vasculature in the brain striatum. Results showed that chronic administration of mirabegron has a modest decrease in sodium, chloride, and potassium levels while increasing calcium serum levels. Moreover, edema and neuronal degeneration have been observed in Wistar rats. In summary, a chronic high dose of beta 3 adrenergic agonist Mirabegron might have a deleterious effect on electrolytes in question homeostasis due to loss of selectivity to beta 3 adrenoceptor when administered in a high dose.