Peer-reviewed veterinary case report
Dog urethral fistula from stone healed with stem cell fat graft
By Karadjole, Tugomir et al.·Published in Croatian medical journal·2024·View original on PubMed →
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Original publication title: Stone-induced urethral fistula treatment with microfragmented adipose tissue containing mesenchymal stem cells: a case report from veterinary medicine with potential application in humans.
- Species:
- dog
Plain-English summary
A 2-year-old male Chow Chow was brought in for a urethral fistula caused by kidney stones. During surgery, the vet found the defect and used a special treatment that involved taking some of the dog's fat and processing it to include stem cells, which help with healing. This mixture was applied around the area where the urethra was repaired. One month later, the dog showed signs of healing, and after a year, there were no further issues. This innovative approach may also have potential benefits for human patients in the future.
People also search for: dog urethral fistula treatment · Chow Chow kidney stones · stem cell therapy for dogs
Abstract
We report on a case of a two-year-old male dog, breed chow-chow, who suffered from urethral fistula as a result of ureterolithiasis. The urethral defect was identified intraoperatively with methylene blue. An autologous regenerative approach was combined with surgical closure of the defect, due to the well-known healing issues of the urethral wall in such conditions. A part of abdominal fat tissue was dissected to produce microfragmented adipose tissue containing mesenchymal stem cells, which was combined with platelet-rich plasma. The final product was applied in the area around the urethral defect closure. One month after the procedure, healing was confirmed with positive-contrast cystography. This therapeutic approach yielded success, and the follow-up period of one year was uneventful. The observed positive outcome of this approach in the canine model may be considered as a starting point for investigating the translational potential of the treatment in human medicine.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38868974/