Peer-reviewed veterinary case report
Stratum corneum removal helps cause mite allergies in atopic dogs
By Olivry, Thierry et al.·Published in Veterinary dermatology·2011·Department of Clinical Sciences, United States·View original on PubMed →
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Original publication title: Stratum corneum removal facilitates experimental sensitization to mite allergens in atopic dogs.
- Species:
- dog
Plain-English summary
A group of Maltese-beagle mix dogs with atopic dermatitis (a skin allergy) had their outer skin layer removed to see if it affected their sensitivity to house dust mites. The dogs that had their skin stripped showed quicker and stronger allergic reactions to the mites compared to those that didn't. This suggests that the outer skin layer helps protect dogs from becoming more allergic to environmental triggers. The study highlights the importance of the skin barrier in managing allergies in dogs.
People also search for: dog skin allergy treatment · Maltese-beagle atopic dermatitis · house dust mite allergy in dogs
Abstract
In humans with atopic dermatitis and in mouse models of IgE-mediated allergic diseases, evidence is mounting that the stratum corneum (SC) provides an important barrier against environmental allergens. At this time, it is not known whether the SC has a similar role in dogs, especially in those with atopic dermatitis. The objectives of this pilot study were to determine whether SC removal led to earlier and stronger sensitization of atopic dogs to Dermatophagoides farinae (Df) house dust mites. Five Maltese-beagle atopic (MBA) dogs were sensitized epicutaneously after the SC was removed with ten tape strips (TS group), while sensitization was done without tape strips in five other MBA dogs (nontape stripping; NTS group). During this 16 week study, sensitization was assessed with allergen-specific IgE serology, intradermal testing with Df allergens and determination of stimulation indices of blood mononuclear cells cultured with Df and stained for CD4 and the activation markers CD25 or CD30. Compared with dogs from the NTS group, those of the TS group exhibited earlier rises in Df-specific IgE serum levels, usually had higher allergen-specific IgE titres, showed higher intradermal test reactivity and had earlier increases and higher percentages of CD25- or CD30-positive activated allergen-specific peripheral CD4-positive T lymphocytes. These observations implicate a role of the SC as a barrier limiting sensitization to exogenous allergens in this experimental atopic dog model.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21143539/