Peer-reviewed veterinary case report
Streptococcus pneumoniae pilus subunits protect mice against lethal challenge.
- Journal:
- Infection and immunity
- Year:
- 2007
- Authors:
- Gianfaldoni, Claudia et al.
- Affiliation:
- Novartis Vaccines and Diagnostics s.r.l. · Italy
- Species:
- rodent
Abstract
Streptococcus pneumoniae is a major public health threat worldwide. The recent discovery that this pathogen possesses pili led us to investigate their protective abilities in a mouse model of intraperitoneal infection. Both active and passive immunization with recombinant pilus subunits afforded protection against lethal challenge with the S. pneumoniae serotype 4 strain TIGR4.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/17145945/