Peer-reviewed veterinary case report
Stress regulates Alzheimer's disease progression via selective enrichment of CD8T cells.
- Journal:
- Cell reports
- Year:
- 2023
- Authors:
- Feng, Yilin et al.
- Affiliation:
- Tsinghua Shenzhen International Graduate School (SIGS) · China
- Species:
- rodent
Abstract
This study investigates stress's impact on Alzheimer's disease (AD) using male APP/PS1 transgenic mice. Negative stressors (chronic social defeat, restraint) and positive hedonia (environmental enrichment, EE) were applied. Stress worsens AD pathology, while EE slows progression. Brain RNA sequencing reveals interleukin-6 (IL-6) and IL-10 as key stress-related AD regulators. Flow cytometry shows that the CD8/CD4T cell ratio shifts in response to stress exposure and EE. Stress exposure increases CD8/CD4ratio, opposite to EE. Depletion and enrichment of CD8T cells both accelerate AD, indicating immune intervention's negative impact. Stress management and balanced immunity may aid AD therapy, highlighting novel potential treatment.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/37858461/