Peer-reviewed veterinary case report
Striatal preprotachykinin gene expression reflects parkinsonian signs.
- Journal:
- Neuroreport
- Year:
- 2004
- Authors:
- Wade, Timothy V & Schneider, Jay S
- Affiliation:
- Department of Pathology · United States
- Species:
- cat
Abstract
Striatal preprotachykinin (PPT) gene expression was measured in MPTP-treated cats when symptomatic and during various stages of recovery from parkinsonism using in situ hybridization histochemistry. Animals expressing severe (1 week post-MPTP) or moderate (3 weeks post-MPTP) parkinsonian sensorimotor deficits had significantly reduced striatal PPT mRNA expression. In contrast, fully recovered animals (6 weeks post-MPTP) had striatal PPT mRNA levels that were not significantly different from normal. Thus, PPT gene expression in the striatum appears to reflect presence or absence of sensorimotor deficits in MPTP-treated cats.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/15538179/