Peer-reviewed veterinary case report
Striatal Serotonin 4 Receptor is Increased in Experimental Parkinsonism and Dyskinesia.
- Journal:
- Journal of Parkinson's disease
- Year:
- 2024
- Authors:
- Cirillo, Rossella et al.
- Affiliation:
- Institut des Sciences Cognitives Marc Jeannerod (ISCMJ) · France
- Species:
- rodent
Abstract
Alterations of serotonin type 4 receptor levels are linked to mood disorders and cognitive deficits in several conditions. However, few studies have investigated 5-HT4R alterations in movement disorders. We wondered whether striatal 5-HT4R expression is altered in experimental parkinsonism. We used a brain bank tissue from a rat and a macaque model of Parkinson's disease (PD). We then investigated its in vivo PET imaging regulation in a cohort of macaques. Dopaminergic depletion increases striatal 5-HT4R in the two models, further augmented after dyskinesia-inducing L-Dopa. Pending confirmation in PD patients, the 5-HT4R might offer a therapeutic target for dampening PD's symptoms.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/38339940/