Peer-reviewed veterinary case report
Chromosome changes found in dog skin mast cell tumors
By Vozdova, Miluse et al.·Published in Journal of applied genetics·2019·Central European Institute of Technology - Veterinary Research Institute·View original on PubMed →
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Original publication title: Structural and copy number chromosome abnormalities in canine cutaneous mast cell tumours.
- Species:
- dog
Plain-English summary
A study found that mast cell tumors, which are the most common skin tumors in dogs, show various genetic abnormalities that could affect their behavior and treatment. Researchers discovered changes in the chromosomes of these tumors, including some that were present in a majority of the cases studied. This suggests that these tumors may be unstable genetically, which could influence how they grow and respond to treatment. More research is needed to understand how these genetic changes might impact a dog's prognosis or the likelihood of the tumor returning after treatment.
People also search for: dog skin tumor treatment · mast cell tumor in dogs prognosis · canine cancer genetic testing
Abstract
Mast cell tumours (MCTs) are the most common skin tumours in dogs. Their clinical behaviour is variable and their aetiology remains largely unknown. We performed a metaphase fluorescence in situ hybridisation (FISH) with whole chromosome painting probes, and interphase FISH with BAC probes for 14 cancer-related genes to reveal clonal structural chromosome rearrangements and copy number variants (CNVs) in canine cutaneous MCTs. The metaphase FISH performed in three MCTs revealed several clonal monosomies and trisomies and two different chromosome rearrangements. No centric fusions were detected. The interphase FISH showed a variety of low frequency CNVs for the individual cancer-related genes. The heterogeneous character of the detected abnormalities indicates increased chromosome instability in canine MCTs. The clonal gain of chromosome 11 was detected in 81% (13/16) of the MCTs. Further research is needed to evaluate the significance of this abnormality as prognostic factor for the survival time or recurrence risk assessments in canine cutaneous MCTs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/30284681/