Peer-reviewed veterinary case report
Studies on diagnostic potential of secretory antigens of Mycobacterium bovis.
- Journal:
- Indian journal of experimental biology
- Year:
- 2006
- Authors:
- Trivedi, Shweta et al.
- Affiliation:
- Indian Veterinary Research Institute · India
- Species:
- rodent
Abstract
Culture filtrate proteins (CFPs) of M. bovis were produced by culturing the organism for a period of 3 weeks. These CFPs elicited a good delayed hypersensitivity (DTH) reaction in cattle and guinea pig. However, CFPs showed least cross-reactivity when tested in guinea pigs sensitized with M. bovis BCG and M. phlei. CFPs were found to be well recognized by T-cells of single intradermal test (SIDT) positive cattle and were also sero-reactive. Lymphocyte transformation assay revealed the culture filtrate antigens as major T-cell antigens. CFPs induced a good interferon gamma release as compared to conventional antigen, PPD, thereby highlighting their diagnostic capabilities.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/16430085/