Study of Glutathione S-Transferase, Its Isoenzyme (Pi), and Tumor Markers (CA15-3, HE4) in Breast Carcinoma Patients (Before and After Treatment).

Abstract

Breast cancer is a leading cause of morbidity and mortality among women globally. Tumor markers play a critical role in diagnosis, treatment monitoring, and prognosis. This review focuses on Glutathione S-transferase (GST), particularly its pi isoenzyme (GSTP1), as well as tumor markers CA15-3 and HE4, in breast cancer patients before and after treatment. These markers are crucial for understanding disease progression, assessing treatment efficacy, and developing therapeutic strategies. Glutathione S-transferase, particularly its pi isoenzyme, along with tumor markers CA15-3 and HE4, holds significant promise in the management of breast cancer. Their combined evaluation before and after treatment could provide crucial insights into disease progression, treatment response, and potential recurrence.