Peer-reviewed veterinary case report
Effectiveness of supplements and carprofen for dog hip arthritis pain
By Kampa, Naruepon et al.·Published in Frontiers in veterinary science·2023·Faculty of Veterinary Medicine·View original on PubMed →
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Original publication title: Study of the effectiveness of glucosamine and chondroitin sulfate, marine based fatty acid compounds (PCSO-524 and EAB-277), and carprofen for the treatment of dogs with hip osteoarthritis: A prospective, block-randomized, double-blinded, placebo-controlled clinical trial.
- Species:
- dog
Plain-English summary
A group of 75 dogs with hip osteoarthritis (OA) were treated with either a common pain medication called carprofen, marine-based fatty acids (PCSO-524 and EAB-277), glucosamine and chondroitin sulfate, or a placebo. After 6 weeks, the dogs receiving PCSO-524, EAB-277, and carprofen showed significant improvements in their ability to bear weight compared to those on the placebo or glucosamine. The glucosamine group did not show any notable improvement. This suggests that while glucosamine and chondroitin sulfate are popular, they may not be as effective as the other treatments for managing hip OA pain in dogs.
People also search for: dog hip pain treatment · glucosamine for dogs effectiveness · carprofen for dog arthritis · PCSO-524 for dogs arthritis
Abstract
INTRODUCTION: Glucosamine hydrochloride and chondroitin sulfate are commonly used in dogs with OA, but evidence around efficacy is mixed. This study evaluated the effectiveness of glucosamine and chondroitin sulfate, marine based fatty acid compounds (PCSO-524 and EAB-277), and carprofen for the alleviation of canine hip OA pain. This was a prospective, block-randomized, double-blinded, placebo-controlled clinical trial. METHODS: Seventy-five owned pet dogs with hip OA were assigned randomly into five treatment groups: PCSO-524, Glucosamine and chondroitin sulfate, EAB-277, carprofen, and Placebo (sunflower oil). Peak vertical force (PVF) and subjective orthopedic assessment scores (OAS) were evaluated before treatment (week 0), and at weeks 2, 4, and 6 during treatment. RESULTS: At week 2, the carprofen group showed a significant increase in PVF (3.14 ± 5.33; mean ± SD). After 4 weeks, the increases in PVF of the PCSO-524 (3.90 ± 3.52), EAB-277 (4.17 ± 4.94), and carprofen (3.08 ± 5.87) groups were significant, and significantly greater than placebo (0.08 ± 1.90) and glucosamine (-0.05 ± 6.34) groups. After 6 weeks, the change of PVF in the PCSO-524 (4.14 ± 4.65), EAB-277 (4.45 ± 4.23), and carprofen (4.21 ± 6.52) groups were significant and significantly higher than the placebo group (-0.33 ± 3.65). The change in PVF in the glucosamine group (1.08 ± 5.49) lay between the placebo group and the other treatment groups. The OAS did not show any significant change in any group. DISCUSSION: PCSO-524 and EAB-277, but not glucosamine/chondroitin, resulted in significant improvements in PVF from baseline after 4 weeks, and 6 weeks, and to a similar degree to that seen with carprofen.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/36816197/