Peer-reviewed veterinary case report
How once daily trilostane affects cortisol in dogs with Cushing's
By Bell, R et al.·Published in The Veterinary record·2006·Department of Veterinary Clinical Studies, United Kingdom·View original on PubMed →
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Original publication title: Study of the effects of once daily doses of trilostane on cortisol concentrations and responsiveness to adrenocorticotrophic hormone in hyperadrenocorticoid dogs.
- Species:
- dog
Plain-English summary
A group of dogs with Cushing's disease (hyperadrenocorticism) were treated with a medication called trilostane to see how well it controlled their cortisol levels. In most dogs, trilostane successfully lowered cortisol levels for a few hours, but the effects didn't last all day. Some dogs still showed high cortisol levels even after treatment, indicating that the medication wasn't fully effective for them. This suggests that trilostane might not work well for every dog with Cushing's, especially if their symptoms are severe.
People also search for: dog Cushing's disease treatment · trilostane for dogs · high cortisol levels in dogs
Abstract
The effects of trilostane, a 3beta-hydroxysteroid dehydrogenase inhibitor on basal cortisol concentrations and the results of ACTH stimulation tests in dogs with pituitary-dependent hyperadrenocorticism were investigated. In eight of nine dogs trilostane suppressed the concentration of cortisol below the lower limit of the reference range (<50 nmol/l) for a mean (sd) of 3.5 (2.3) hours during the day, but for no longer than 13 hours. In another 10 dogs, there was a clear difference between the post ACTH cortisol concentrations observed four and 24 hours after the administration of trilostane. Furthermore, in the six dogs whose clinical signs were poorly controlled the post-ACTH concentrations observed four and 24 hours after the administration of trilostane were always higher than the equivalent cortisol concentrations in the four dogs whose clinical signs were controlled. A short duration of drug action may be responsible for the failure of some dogs to respond adequately to once daily trilostane administration.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16946310/