STUDY OF THE IRRITANT EFFECT AND ANTI-INFLAMMATORY ACTIVITY OF THE OINTMENT UBEROSEPT

Abstract

The article presents the results of two series of experiments on studying the local irritant and anti-inflammatory action of a new complex ointment Uberosept. The studies of the anti-inflammatory activity of the drug were carried out on white rats using the zymosan-induced paw edema model. It has been found that the Uberosept ointment possesses pronounced anti-inflammatory properties, that are not inferior to the comparison drug (Hydrocortisone ointment). The experiments to assess the irritant effect of Uberosept were conducted on guinea pigs. The animals were applied the complex ointment at doses of 0.12 and 0.6 g to the skin used as a single dose, and at a dose of 0.12 g for 14 days. Based on the conducted studies, it can be concluded that the ointment Uberosept does not cause an irritant effect on the skin with a single or long-term use.