Peer-reviewed veterinary case report
Study on SSAO enzyme activity and anti-inflammatory effect of SSAO inhibitors in animal model of inflammation.
- Journal:
- Journal of neural transmission (Vienna, Austria : 1996)
- Year:
- 2013
- Authors:
- Tábi, Tamás et al.
- Affiliation:
- Department of Pharmacodynamics
- Species:
- rodent
Abstract
SSAO/VAP-1 participates in the accumulation of leukocytes at the site of inflammation. A new SSAO inhibitor, SzV-1287 was demonstrated to inhibit both acute and chronic inflammation in rats more effectively than the known enzyme inhibitor, LJP-1207. Surprisingly, the SSAO activity was not increased, but decreased both in acute and chronic inflammation. Though experiments are in progress to clarify these findings, the enzyme might play a role in the very early phase of inflammation and be inactivated during leukocyte extravasation.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/23263543/