Study on the Effect and Mechanism of Lomatogonium rotatum (L.) Fries ex Nym Extract on NAFLD Through Metabolomics.

Abstract

Lomatogonium rotatum (L.) Fries ex Nym. is one of the traditional Mongolian medicines in the "Digeida" category. It has the effects of calming Xieri (a concept in Mongolian medicine) and clearing heat and promoting diuresis and is used for the treatment of diseases such as fever, headache, plague, typhoid, jaundice, and liver and gallbladder heat. However, the mechanism of its flavonoid compounds in the treatment of non-alcoholic fatty liver disease (NAFLD) is not yet clear. In this study, a NAFLD mouse model was established by feeding mice with a choline-deficient high-fat (CDHF) diet for 8 weeks. The relevant indicators in the serum and tissues of mice in each group were measured. The compounds in the L-30 elution fraction were identified by LC-MS technology, and the liver metabolomics was determined. The results showed that the L-30 elution fraction was an enrichment site of flavonoid compounds, and the L-30 elution fraction could effectively alleviate lipid deposition in the liver of NAFLD mice and relieve liver metabolic disorders.