Peer-reviewed veterinary case report
Study on the molecular aspect of cardioprotective effects of selenium: a mini-review.
By Roshanravan N et al.·2025·48432 Tabriz University of Medical Sciences·View original on Europe PMC →
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Plain-English summary
This study looks at selenium, an important nutrient that can help protect the heart. It highlights how selenium has strong antioxidant (fights damage from harmful molecules), anti-inflammatory (reduces swelling), and antiviral (fights viruses) effects, which are important because heart disease is a major cause of death and disability. The researchers reviewed a lot of scientific information to understand how selenium works at a molecular level to reduce heart problems and related issues. Overall, the study explains how selenium can be beneficial for heart health by targeting specific biological pathways.
Abstract
Selenium (Se) is an essential micronutrient with multiple and complex effects on human health, including potent antioxidant, anti-inflammatory, and antiviral properties. Cardiovascular disease (CVD) and its most severe complications are the leading causes of mortality and disability worldwide. Considering the fact that oxidative stress and inflammation are central to CVDs, this review focuses on different cardioprotective characteristics of Se with a special focus on molecular mechanisms. In this review, several databases, websites, and search engines, including Medline, PubMed, Scopus, ScienceDirect, and Google Scholar, were searched using MeSH keywords of Se, Se compounds, CVD, oxidative stress, inflammation, coronary artery disease, and signaling pathway. The present study thoroughly explains the molecular pathways by which Se carries out its function to decrease cardiovascular and related diseases.
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Search related cases →Original publication on Europe PMC: https://europepmc.org/article/MED/40738121