Peer-reviewed veterinary case report
Treating low adrenal hormone disease in dogs with under-the-skin
By McCabe, M D et al.·Published in Journal of the American Animal Hospital Association·1995·Veterinary Medical Teaching Hospital, United States·View original on PubMed →
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Original publication title: Subcutaneous administration of desoxycorticosterone pivalate for the treatment of canine hypoadrenocorticism.
- Species:
- dog
Plain-English summary
Twelve dogs with low adrenal hormone levels (hypoadrenocorticism) were treated with a medication called desoxycorticosterone pivalate (DOCP) given under the skin. Eight of these dogs were newly diagnosed and had not received treatment before, while four had been treated previously with other medications. After starting the DOCP treatment, the dogs' blood tests showed that their sodium and potassium levels returned to normal, indicating that the treatment was effective. All dogs maintained normal blood values throughout the study, suggesting that this treatment is a good option for managing this condition.
People also search for: dog low adrenal hormone treatment · hypoadrenocorticism in dogs · desoxycorticosterone pivalate for dogs
Abstract
Twelve dogs with hypoadrenocorticism were treated with subcutaneous desoxycorticosterone pivalate (DOCP). Eight of these dogs were recently diagnosed and had not yet been treated. Four dogs previously had been diagnosed and treated (three with intramuscular DOCP, one with oral fludrocortisone acetate). History, physical examination, serum electrolytes, and blood urea nitrogen (BUN) were evaluated. Desoxycorticosterone pivalate (2.2 mg/kg body weight) was administered every 25 days. On day 0, recently diagnosed dogs had a median serum sodium concentration of 131.5 mEq/L, median serum potassium concentration of 6.6 mEq/L, and median BUN of 41.5 mg/dl. All subsequent median serum electrolyte and BUN concentrations were normal. All previously treated dogs had normal blood values which were maintained throughout the study.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/7773761/