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Peer-reviewed veterinary case report

Subretinal Transplant of Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium on Nanostructured Fibrin-Agarose.

Journal:
Tissue engineering. Part A
Year:
2019
Authors:
García Delgado, Ana B et al.
Affiliation:
1 Regeneration and Cell Therapy Department · Spain

Abstract

In the promising field of cellular therapy for retinal degenerative diseases, a new biomaterial is proposed as a scaffold to grow and surgically introduce a monolayer of retinal pigment epithelial cells into the subretinal space, keeping the orientation of the cells for a proper functional integration of the transplant. The use of induced pluripotent stem cells as the starting material for retinal pigment epithelial cells is intended to advance toward a personalized medicine approach.

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Original publication: https://pubmed.ncbi.nlm.nih.gov/30963803/