Peer-reviewed veterinary case report
Treatment success for colonic pythiosis in 3 dogs with antifungals
By Reagan, Krystle L et al.·Published in Journal of veterinary internal medicine·2019·Veterinary Medical Teaching Hospital, United States·View original on PubMed →
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Original publication title: Successful management of 3 dogs with colonic pythiosis using itraconzaole, terbinafine, and prednisone.
- Species:
- dog
Plain-English summary
Three dogs with severe gastrointestinal pythiosis, a dangerous infection affecting the colon, were treated successfully with a combination of antifungal medications (itraconazole and terbinafine) and corticosteroids (prednisone). These dogs showed significant improvement, with their clinical symptoms resolving and the masses in their colons shrinking. Additionally, blood tests indicated a decrease in infection markers. This treatment approach offers hope for dogs with this serious condition when surgery isn't an option.
People also search for: dog colonic pythiosis treatment · itraconazole for dogs · prednisone for dog infections
Abstract
Gastrointestinal (GI) pythiosis is a severe and often fatal disease in dogs that traditionally has been poorly responsive to medical treatment. Although aggressive surgical resection with wide margins is the most consistently effective treatment, lesion location and extent often preclude complete resection. Recently, it has been suggested that the addition of anti-inflammatory doses of corticosteroids may improve outcome in dogs with nonresectable GI pythiosis. This report describes 3 dogs with colonic pythiosis in which complete resolution of clinical signs, regression of colonic masses, and progressive decreases in serological titers were observed after treatment with itraconazole, terbinafine, and corticosteroids. This treatment protocol represents a promising treatment for dogs with GI pythiosis in which surgical intervention is not feasible.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31004383/